Publications by authors named "M Childs"

Article Synopsis
  • - Regulatory CD8 T cells (CD8 Treg) usually help control harmful CD4 T cells, but in autoimmune diseases, they often fail, partly due to inhibitory receptors that limit their activation.
  • - A new bispecific antibody called MTX-101 targets these inhibitory receptors and CD8 T cells to enhance the ability of CD8 Treg to eliminate pathogenic CD4 T cells in various experimental models.
  • - In studies, MTX-101 improved CD8 Treg activity, reduced harmful CD4 T cell expansion, and protected tissues from damage without triggering excessive inflammation, showing promise for treating autoimmune disorders.
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Objective: Recent shifts in U.S. violence dynamics call for updated violence epidemiology among general emergency department (ED) samples of young adults.

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Skin cancer risk is increased by exposure to ultraviolet radiation (UVR). Because UVR exposure accumulates over time and lighter skin is more susceptible to UVR, age and skin tone are risk factors for skin cancer. However, measurements of somatic mutations in healthy-appearing skin have not been used to calculate skin cancer risk.

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Climate change poses significant threats to public health, with dengue representing a growing concern due to its high existing burden and sensitivity to climatic conditions. Yet, the quantitative impacts of temperature warming on dengue, both in the past and in the future, remain poorly understood. In this study, we quantify how dengue responds to climatic fluctuations, and use this inferred temperature response to estimate the impacts of historical warming and forecast trends under future climate change scenarios.

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