Publications by authors named "M Chevignard"
Long-Term Clinical and Biological Prognostic Factors of Anti-NMDA Receptor Encephalitis in Children.
Neurol Neuroimmunol Neuroinflamm
March 2025
Background And Objectives: Anti-NMDAR encephalitis (NMDARE) is a severe neurologic condition, and recently, the NMDAR Encephalitis One-Year Functional Status (NEOS) score has emerged as a 1-year prognostic tool. This study aimed to evaluate NEOS score and biomarker (neurofilament light chains [NfL], total-Tau protein, glial fibrillary acidic protein, and serum cytokines) correlation with modified Rankin Scale (mRS), cognitive impairment, and clinical recovery in pediatric NMDARE over 2 years.
Methods: In this French multicenter observational study, 104 pediatric patients with NMDARE were followed for a minimum of 2 years.
Introduction: Early focal brain injuries lead to long-term disabilities with frequent cognitive impairments, suggesting global dysfunction beyond the lesion. While plasticity of the immature brain promotes better learning, outcome variability across individuals is multifactorial. Males are more vulnerable to early injuries and neurodevelopmental disorders than females, but long-term sex differences in brain growth after an early focal lesion have not been described yet.
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- This study explored the recovery trajectories of Dizziness-Related Disability (DRD) in kids aged 8-17 who experienced concussions, using evaluations over 6 months.
- Two main recovery groups were identified: a Low DRD group (79% of participants) and a High DRD group (21%).
- Key factors predicting membership in the High DRD group included chronic neck pain, existing anxiety issues, and scores from a specific assessment tool (the 5P total score), highlighting the need for personalized treatment approaches.
Predicting and improving outcome in severe pediatric traumatic brain injury.
Expert Rev Neurother
October 2024
Introduction: Severe pediatric traumatic brain injury (spTBI), including abusive head trauma (AHT) in young children, is a major public health problem. Long-term consequences of spTBI include a large variety of physical, neurological, biological, cognitive, behavioral and social deficits and impairments.
Areas Covered: The present narrative review summarizes studies and reviews published from January 2019 to February 2024 on spTBI.