The impact of hyperthermic intraperitoneal chemotherapy and cytoreductive surgery on clinical outcomes and quality of life of patients with peritoneal carcinomatosis.

Aim Of The Study: To investigate the impact of hyperthermic intraperitoneal chemotherapy (HIPEC) on the clinical and oncological outcomes and quality of life (QOL) of patients with peritoneal carcinomatosis (PC).

Material And Methods: The study involved 304 patients with PC of different origin, who were divided into 2 groups: Group I - cytoreductive surgery (CRS) + adjuvant chemotherapy (ACT) - 247 patients; Group II - CRS + HIPEC + ACT - 57 patients. Intraoperative characteristics and postoperative complications were compared.

MULTIPLE INTERVAL DEBULKING SURGERY IN RECURRENT UTERINE SARCOMA (CASE REPORT).

We report a case of a 61-year-old woman, who had been suffering from multiple relapses of uterine sarcoma treated by multiple cytoreduction operations. During the observation period there were performed 13 surgical interventions. As a result of operations, together with the removal of more than 60 liters of tumor volume, the following were performed: extirpation of the uterus with ovaries, right colectomy, resection of the small intestine four times, resection of the sigmoid colon, resection of the duodenum, peritonectomy, cholecystectomy, appendectomy, 2 cycles of adjuvant chemotherapy and Hyperthermic intraperitoneal chemotherapy procedure.

Implementation of the enhanced recovery after surgery protocol for patients with peritoneal carcinomatosis undergoing cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion.

Aim Of The Study: To investigate the feasibility of enhanced recovery after surgery (ERAS) protocol for patients with primary peritoneal carcinomatosis (PC) undergoing cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (HIPEC) based on the length of hospital stay (LOS), return of bowel function, the incidence of postoperative complications, and quality of life (QLQ) analysis.

Material And Methods: The study included a total of 37 patients with primary PC of different origin, who underwent cytoreductive surgery plus HIPEC. Patients were divided into 2 groups: Group I (nonERAS) - 20 patients and Group II (ERAS) - 17 patients.

[Effect of cytokines and stromal cells of adipose tissue on integration of a two-component composite net imlant into biological tissues].

Morphological changes in biological tissues, surrounding the composite net-like implant, owing large pores "Ultrapro", and also its combination with adipose transplant, fibrin, enriched with thrombocytes, were studied in experiment on 36 adult male rats of a Wistar line. While application of such construction the processes of creation and organization of connective tissue, neoangiogenesis as well as development of a new adipose tissue are improved. As a consequence of increase of concentration of highly active biological substances and regenerative cytokines in combination of the net implant with adipose transplant, containing multipotent stem cells, proliferative activity of all cellular elements, surrounding the net implant, is raising, what predispose its optimal integration into surrounding tissues.