Publications by authors named "M Chelli Bouaziz"
Improving the selectivity and effectiveness of drugs represents a crucial issue for future therapeutic developments in immuno-oncology. Traditional bulk transcriptomics faces limitations in this context for the early phase of target discovery as resulting gene expression levels represent the average measure from multiple cell populations. Alternatively, single cell RNA sequencing can dive into unique cell populations transcriptome, facilitating the identification of specific targets.
View Article and Find Full Text PDFThis study aimed to evaluate the impact of olive leaf extract (OLE) on the quality of Cantal cheese. The cheeses were fortified with different concentrations (Control, 1, 2, and 3 %) of OLE and analysed for quality during storage. The cheeses were evaluated on days 1, 28, and 63 for physicochemical, compositional, textural, rheological parameters, colour, microbiological analysis, and antioxidant activity.
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- Peters anomaly, a leading cause of congenital corneal opacity, is linked to corneal-lenticular adhesion and is tied to unidentified mutations and a complex disease mechanism.
- Abl kinases have been discovered as key regulators of FGF signaling, with their genetic deletion allowing lens formation even when FGF is missing, and their role appears independent of traditional ERK signaling pathways.
- The study suggests that targeting the Ptpn12-p130Cas pathway, which is influenced by Abl kinases, could offer therapeutic possibilities for addressing Peters anomaly by improving lens vesicle separation dynamics.
Article Synopsis
- Severe scorpion envenomation can lead to temporary myocardial ischemia, which is rarely reported but supported by various studies, including electrocardiograms and echocardiography.
- This myocardial hypoperfusion may arise from catecholamine storms causing microvascular constriction and other neurohormonal interactions that contribute to cardiac fiber damage.
- Management includes providing oxygen and ventilator support, and while dobutamine can aid cardiac function, antiplatelet therapy is not recommended.