Ghrelin recruits the endocannabinoid system to modulate food reward.

Ghrelin enhances feeding by activating the growth hormone secretagogue receptor (GHSR). In the brain, GHSRs are expressed in regions responsible for regulating food motivation including the ventral tegmental area (VTA). Endogenous cannabinoids also promote food seeking behaviors through the cannabinoid receptor 1 type (CB-1Rs) in brain regions including the VTA.

Associations between shorter leucocyte telomere length and increased risk of age-related macular degeneration in women: insights from the United Kingdom Biobank study.

Objectives: To determine the association between telomere length (TL) and age-related macular degeneration (AMD) and examine the potential variations with sex and ethnicity.

Methods: Population-based, cross-sectional study. A total of 52,083 participants from the UK Biobank were included.

Navajo Verbs in Child Speech.

This study investigates Navajo verbs produced by four children, ages 4;07 to 11;02, during conversations with their caretakers. Analyses of 1600 verbs demonstrate that the bisyllabic verb form, consisting of a verb stem and a portion of the prefix string, is the most common pattern produced by the children. This indicates that Navajo-speaking children use meaningful units of verbal morphology that do not necessarily adhere to the linguistic boundaries normally ascribed to the Navajo verb complex.

Evaluation of Brain Age as a Specific Marker of Brain Health.

Brain age is a powerful marker of brain health. Furthermore, brain age models are trained on large datasets, thus giving them a potential advantage in predicting outcomes - much like the success of finetuning large language models for specific applications. However, it is also well-accepted in machine learning that models trained to directly predict specific outcomes (i.