Publications by authors named "M Charlier"
Background: Despite the high prevalence of neuropathic pain, treating this neurological disease remains challenging, given the limited efficacy and numerous side effects associated with current therapies. The complexity in patient management is largely attributed to an incomplete understanding of the underlying pathological mechanisms. Central sensitization, that refers to the adaptation of the central nervous system to persistent inflammation and heightened excitatory transmission within pain pathways, stands as a significant contributor to persistent pain.
View Article and Find Full Text PDFLactation is an essential process for mammals. In sheep, the R96C mutation in suppressor of cytokine signaling 2 (SOCS2) protein is associated with greater milk production and increased mastitis sensitivity. To shed light on the involvement of R96C mutation in mammary gland development and lactation, we developed a mouse model carrying this mutation (SOCS2KI/KI).
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- Milk from the miR-30b transgenic mice has a different fatty acid profile and significantly affects the growth of wild-type pups, causing early growth defects when they are fed this milk.
- The study focused on how miR-30b milk impacts the duodenal development of wild-type pups by comparing their duodenums at different postnatal days using various scientific analyses.
- Results showed that miR-30b milk led to changes in duodenal protein expression and permeability, and it contained higher levels of lipids, ceramides, and insulin, suggesting it alters nutrient absorption and gut development in the pups.
Nulliparity is associated with intra-uterine growth retardation and foal delayed catch-up growth. Older mares produce larger/taller foals than the precedents. Nursing at conception on foal growth had not been investigated yet.
View Article and Find Full Text PDFTeamwork training and evaluation are essential to enhance safety and quality of care. The lack of the psychometric testing of the TeamSTEPPS® Teamwork Attitudes Questionnaire (T-TAQ) and Teamwork Perceptions Questionnaire (T-TPQ) across different language and cultural settings has questioned their widespread use because such attitudes and perceptions are highly subjective and context-bound. The present study aims to translate the T-TAQ and T-TPQ into the French language and validate the psychometric properties of the two questionnaires in a public health context.
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