Publications by authors named "M Chamekh"
Sex-biased expression of selected chromosome x-linked microRNAs with potent regulatory effect on the inflammatory response in children with cystic fibrosis: A preliminary pilot investigation.
Front Immunol
April 2023
Previous studies have reported sex disparity in cystic fibrosis (CF) disease, with females experiencing more pulmonary exacerbations and frequent microbial infections resulting in shorter survival expectancy. This concerns both pubertal and prepubertal females, which is in support to the prominent role of gene dosage rather than the hormonal status. The underlying mechanisms are still poorly understood.
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- A study investigated the differences in innate inflammatory responses between male and female mice infected with group B streptococcal pneumoniae, revealing males had a stronger inflammatory response despite similar bacterial loads.
- Males showed a higher proportion of pro-inflammatory M1 macrophages compared to females, while females had a greater expression of the microRNA-223-3p, which is linked to anti-inflammatory responses.
- The research suggests that the varying levels of miR-223-3p between sexes may influence macrophage polarization and the overall inflammatory response during infection, highlighting the biological differences in men and women regarding inflammatory diseases.
Understanding Gender-Bias in Critically Ill Patients With COVID-19.
Front Med (Lausanne)
September 2020
Group B streptococcus (GBS) is a human-pathogenic bacterium inducing a strong inflammatory response that may be detrimental for host tissues if not finely regulated. The inflammatory response can be modulated by different molecular mechanisms, among which growing evidence points toward the crucial role of microRNAs (miRNAs). Regarding innate inflammatory response, studies have reported that miR-223 is essential for the control of granulocyte proliferation and activation.
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