Publications by authors named "M Chamberland"
White matter alterations are increasingly implicated in neurological diseases and their progression. International-scale studies use diffusion-weighted magnetic resonance imaging (DW-MRI) to qualitatively identify changes in white matter microstructure and connectivity. Yet, quantitative analysis of DW-MRI data is hindered by inconsistencies stemming from varying acquisition protocols.
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- Visualizing brain scans helps researchers check the quality of their data and understand what it means.
- This survey looks at a special type of brain imaging called diffusion MRI tractography, which is used a lot in science and medicine.
- The study reviews 27 different tools that help visualize this type of data, helping beginners and experts find the right tools by showing what features each one has.
In response to a growing interest in refining brain connectivity assessments, this study focuses on integrating white matter fiber-specific microstructural properties into structural connectomes. Spanning ages 8-19 years in a developmental sample, it explores age-related patterns of microstructure-informed network properties at both local and global scales. First, the diffusion-weighted signal fraction associated with each tractography-reconstructed streamline was constructed.
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- Neuroanatomical changes during adolescence, observed through MRI, show significant cortical thinning and volume loss, but the cellular mechanisms behind these changes have not been clearly understood until now.
- Recent advancements in MRI technology allowed researchers to analyze the microstructure of the cortex in children and adolescents, revealing that neurite signal increases and soma radius decreases with age, indicating ongoing neural development.
- The study also found an increase in gene expression related to oligodendrocytes and excitatory neurons, suggesting that myelination processes are crucial for cortical maturation during adolescence and into early adulthood.
Background And Objectives: Endoscopic endonasal surgery is a well-established surgical approach to the skull base. Surgeons need a reusable long-lasting tool to acquire the skills needed for skull base reconstruction. The aim of this study was to elaborate and validate a human formalin-fixed cadaveric model that reproduces a realistic cerebrospinal fluid (CSF) circulation and that adequately renders a CSF leak.
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