Assessment of pyloric sphincter distensibility and pressure in patients with diabetic gastroparesis.

Background: Recent studies have shown that pyloric distensibility is altered in 30-50% of gastroparetic patients but the number of diabetic patients included in prior reports has been small. The aim of the present study was to assess pyloric sphincter measurements in diabetic patients with gastroparesis and to determine whether diabetes characteristics were correlated to pyloric disfunction.

Methods: Pyloric distensibility and pressure were measured using EndoFLIP system in 46 patients with diabetic gastroparesis (DGP) and compared with 21 healthy volunteers (HV), and 33 patients with idiopathic gastroparesis (IGP).

Solitary rectal ulcer syndrome in 102 patients: Do different phenotypes make sense?

Background: Little is known about the pathophysiological mechanisms of solitary rectal ulcer syndrome (SRUS).

Aims: We aim to identify the different phenotypes, taking into account complaints, anatomy and anorectal physiology.

Methods: Complaints, endoscopy results, and physiology data of patients with histologically proven SRUS were collected and analysed.

Assessment of tissue oxygenation to personalize mean arterial pressure target in patients with septic shock.

Objective: To investigate whether assessment of tissue oxygenation could help personalizing the mean arterial pressure (MAP) target in patients with septic shock.

Methods: We prospectively measured near-infrared spectroscopy variables in 22 patients with septic shock receiving norepinephrine with a MAP>75 mmHg within the first six hours of intensive care unit (ICU) stay for patients with community-acquired septic shock and within the first six hours of resuscitation for patients with ICU-acquired septic shock. All measurements were performed at MAP>75 mmHg ("high-MAP") and at MAP 65-70 mmHg ("low-MAP") after decreasing the norepinephrine dose.

Management of solitary rectal ulcer syndome: Results of a french national survey: Société Nationale Française de Coloproctologie SNFCP, France.

There is no consensus on the treatment for solitary rectal ulcer syndrome (SRUS). This study aimed to obtain information from physicians treating patients with SRUS in a French medical surgical society to facilitate management plans and to develop a support algorithm. Members of the French National Society of Coloproctology (SNFCP) were invited to complete a survey that included twenty items about therapeutic management and healing criteria.

Pituitary dysmaturation affects psychopathology and neurodevelopment in 22q11.2 Deletion Syndrome.

Background: 22q11.2 Deletion Syndrome (22q11DS) confers strongly increased genetic risk for multiple psychiatric disorders. Similarly to the general population, rates of psychiatric comorbidity suggest that common disease mechanisms are shared across dimensions of psychopathology.