Publications by authors named "M Cerghet"
Article Synopsis
- Multiple sclerosis (MS) is difficult to diagnose and manage, often leading to late treatment; however, artificial intelligence (AI) shows promise in analyzing patient data to improve diagnosis.* -
- This study employed a machine-learning approach to analyze metabolite profiles in MS patients and healthy controls, uncovering unique biochemical changes linked to disease severity.* -
- A trained AI model achieved high accuracy rates (87% overall, with good sensitivity, specificity, and precision), indicating potential for clinical use, but further validation with larger studies is required.*
Article Synopsis
- Multiple sclerosis (MS) is the most common inflammatory neurodegenerative disease affecting young adults, manifesting primarily as relapsing-remitting MS (RRMS) and progressing to secondary progressive MS (SPMS) or existing as primary progressive MS (PPMS), which has a steady decline without remission.
- Researchers conducted a study using global untargeted metabolomics to identify specific altered metabolites in the serum of patients with RRMS, PPMS, and healthy subjects (HS), analyzing a total of 235 metabolites.
- The study found significant differences in metabolite profiles between RRMS and HS (22 metabolites) as well as PPMS and HS (28 metabolites), and identified key metabolic pathways involved, suggesting that these unique altered metabolites could help differentiate
Article Synopsis
- The study aimed to analyze the clinical features, radiological outcomes, treatments, and long-term follow-up of patients diagnosed with spinal cord neurosarcoidosis over a 25-year period at a single medical center.
- A total of 39 patients were reviewed, with most showing extensive intramedullary lesions and common symptoms like neuropathic pain and weakness, leading to a prevalent use of corticosteroids and methotrexate for treatment.
- Follow-up MRI results indicated improvements over time, with a notable percentage of patients experiencing complete resolution of MRI enhancements, highlighting the need for better diagnostic clarity and treatment guidelines due to the complexity of the condition.
Article Synopsis
- * CVD complications in MS patients can worsen brain damage, increasing the severity of the disease, but the exact prevalence of cardiovascular problems in MS remains largely unknown and inconsistent.
- * More research, including preclinical studies with animal models, is needed to understand how MS affects cardiac function; clinicians should also monitor cardiovascular health when treating MS patients, as some medications may contribute to CVD risks.
Objective: To describe the radiological features of patients with headache as a presenting symptom of neurosarcoidosis.
Background: Neurologic complications occur in approximately 5%-10% of patients with sarcoidosis, and approximately 50% of these patients have neurologic deficits at the time sarcoidosis is first diagnosed. A wide spectrum of central and peripheral nervous system clinical manifestations may be observed, including cranial nerve palsies, sensory and/or motor deficits, and headache.