Angiogenesis and Ewing sarcoma--relationship to pulmonary metastasis and survival.

Background/purpose: Intratumoral angiogenesis quantified by microvessel density (MVD) has been shown to be a strong prognostic indicator in a number of malignant tumors. Its association with prognosis in Ewing sarcoma has not been previously studied. The aim of our study was to investigate the relationship between angiogenesis and clinical outcome in Ewing sarcoma.

Tumor angiogenesis and outcome in osteosarcoma.

Intratumoral angiogenesis quantified by microvessel density (MVD) has been shown to be a strong prognostic indicator in a number of malignant tumors. Its association with prognosis in bone sarcomas has been subject to less extensive research. The aim of this study was to investigate prognostic significance of angiogenesis in osteosarcoma.

Osteosarcoma and Ewing's sarcoma in children and adolescents: retrospective clinicopathological study.

Aim: Almost 20 different prognostic factors have so far been investigated in childhood bone tumors, but apart from clinical stage the results have been inconclusive. We evaluated possible prognostic factors of malignant bone tumors in children and adolescents.

Methods: Seventy children and adolescents, who have been treated for bone sarcomas (36 with osteosarcoma and 34 with Ewing's sarcoma) at the Children's Hospital in Zagreb and the Orthopedic Clinic of the Zagreb University School of Medicine were included in the study.

Embryonal rhabdomyosarcoma with 92,XXYY, +dmin and evidence of spontaneous cell fusion.

The results of a cytogenetic analysis in an embryonal rhabdomyosarcoma are presented. A tetraploid karyotype with double minute chromosomes (dmin) was identified using a direct method of tumor tissue treatment. In 5% of the examined cells, evidence of spontaneous cell fusion was observed.