Publications by authors named "M Celeste Nicolao"
Parasites possess remarkable abilities to evade and manipulate the immune response of their hosts. is a parasitic tapeworm that causes cystic echinococcosis in animals and humans. The hydatid fluid released by the parasite is known to contain various immunomodulatory components that manipulate host´s defense mechanism.
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- - The study focuses on the
- Echinococcus granulosus
- species, which causes cystic echinococcosis, investigating how small extracellular vesicles (sEVs) from the parasite interact with host immune cells and affect disease progression, especially during pharmacological treatments.
- - Researchers isolated and characterized sEVs from both untreated and drug-treated parasites, revealing over 500 proteins within these vesicles that are associated with immune response regulation and drug action.
- - Findings indicate that sEVs derived from treated parasites, particularly those treated with metformin and albendazole sulfoxide, enhance the immune response in mouse dendritic cells, raising levels of pro-inflammatory cytokines such as IL-12, IL-
Alveolar echinococcosis (AE) is a severe disease caused by Echinococcus multilocularis. Its chemotherapeutic treatment is based on benzimidazoles, which are rarely curative and cause several adverse effects. Therefore, it is necessary to develop alternative and safer chemotherapeutic strategies against AE.
View Article and Find Full Text PDFImmune evasion is a hallmark of persistent echinococcal infection, comprising modulation of innate immune cells and antigen-specific T cell responses. However, recognition of Echinococcus granulosus by dendritic cells (DCs) is a key determinant of the host's response to this parasite. Given that mTOR signaling pathway has been described as a regulator linking metabolism and immune function in DCs, we reported for the first time in these cells, global translation levels, antigen uptake, phenotype, cytokine transcriptional levels, and splenocyte priming activity upon recognition of the hydatid fluid (HF) and the highly glycosylated laminar layer (LL).
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- In 2008, guidelines were established for researching autophagy, which has since gained significant interest and new technologies, necessitating regular updates to monitoring methods across various organisms.
- The new guidelines emphasize selecting appropriate techniques to evaluate autophagy while noting that no single method suits all situations; thus, a combination of methods is encouraged.
- The document highlights that key proteins involved in autophagy also impact other cellular processes, suggesting genetic studies should focus on multiple autophagy-related genes to fully understand these pathways.