Publications by authors named "M Cedeno"
Air pollution is a global health challenge, increasing the risk of cardiovascular diseases such as heart disease, stroke, and arrhythmias. Particulate matter (PM), particularly PM2.5 and ultrafine particles (UFP), is a key contributor to the adverse effects of air pollution on cardiovascular health.
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- The study explores how a compound called c28MS can simultaneously inhibit glycolysis and glutaminolysis in rheumatoid arthritis synovial fibroblasts (RAFLS), potentially offering a new treatment strategy for the disease.
- Researchers used single-cell RNA sequencing (scRNA-seq) and metabolomic analysis to identify key metabolic pathways involved in RAFLS and found that c28MS reduced aggressive behavior in these cells and lowered arthritis severity in lab mice.
- The results suggest that targeting multiple metabolic pathways could be a promising therapeutic approach not only for rheumatoid arthritis but also for other non-cancer diseases.
Background: Glucose metabolism, specifically, hexokinase 2 (HK2), has a critical role in rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS) phenotype. HK2 localizes not only in the cytosol but also in the mitochondria, where it protects mitochondria against stress. We hypothesize that mitochondria-bound HK2 is a key regulator of RA FLS phenotype.
View Article and Find Full Text PDFInborn errors of immunity are a group of rare genetically determined diseases that impair immune system development or function. Many of these diseases include immune dysregulation, autoimmunity, or autoinflammation as prominent clinical features. In some children diagnosed with very early onset inflammatory bowel disease (VEOIBD), monogenic inborn errors of immune dysregulation underlie disease.
View Article and Find Full Text PDFBackground: Seronegative elderly-onset rheumatoid arthritis (EORA) and polymyalgia rheumatica (PMR) have similar clinical characteristics making them difficult to distinguish based on clinical features. We hypothesized that the study of serum metabolome could identify potential biomarkers of PMR vs. EORA.
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