Publications by authors named "M Causevic"
Article Synopsis
- In December 2019, a new coronavirus, SARS-CoV-2, triggered a global pandemic that negatively impacted people's psychological needs due to isolation, fear, and economic downturns.
- The research aimed to explore how the COVID-19 pandemic affected the mental health and perceived social support of individuals with disabilities in Bosnia and Herzegovina, using tools to measure symptoms of depression, anxiety, and social support.
- Findings indicated that individuals with disabilities who contracted the virus experienced higher levels of somatization, anxiety, and depression compared to those who were not infected, highlighting the need for targeted mental health interventions for this population in the future.
Glucagon-Like Peptide-1 Receptor Agonists and Brain Vascular Function.
Heart Lung Circ
November 2021
Prevention of cardiovascular events and regression of atherosclerotic changes are the primary aims of preventive cardiovascular medicine. Arterial thrombosis is caused by endothelial dysfunction, which disrupts vascular haemostasis. Glucagon-like peptide 1 (GLP-1) receptor agonists have been initially used as glucose lowering agents, but over time have been used for other indications due to their cardiorenal benefit, as well as their benefit in the regression of atherosclerosis process.
View Article and Find Full Text PDFBackground: Alzheimer's disease is a complex disorder of unclear etiology that develops in the elderly population. It is a debilitating, progressive neurodegeneration for which disease-modifying therapies do not exist. Previous studies have suggested that, for a subset of patients, dysregulation in hemostasis might be one of the molecular mechanisms that ultimately leads to the development of neurodegeneration resulting in cognitive decline that represents the most prominent symptomatic characteristic of Alzheimer's disease.
View Article and Find Full Text PDFAlzheimer's disease represents the most common age-related neurodegenerative disorder and a leading cause of progressive cognitive impairment. Predicting cognitive decline is challenging but would be invaluable in an increasingly aging population which also experiences a rising cardiovascular risk. In order to examine whether plasma measurements of one of the established biomarkers of heart failure, brain natriuretic peptide (BNP), reflect a decline in cognitive function, associated with Alzheimer's disease neurodegeneration, BNP levels were analysed, by using a novel assay called a SOMAscan, in 1.
View Article and Find Full Text PDFArticle Synopsis
- Niemann-Pick type C (NPC) is a rare lysosomal storage disorder that shares features with Alzheimer’s disease, particularly in the processing of amyloid precursor protein by the enzyme BACE1.
- The study focused on analyzing the expression of BACE1 substrates Sez6, Sez6L, and APP in mouse brains at two different ages to observe changes associated with NPC and its progression.
- Results revealed increased BACE1 cleavage of these substrates in NPC mice, indicating a potential trafficking defect in the endolysosomal pathway that may enhance proteolytic activity, which could inform therapeutic strategies for both NPC and Alzheimer's disease.