Publications by authors named "M Catherine Hough"
Article Synopsis
- Serial crystallography involves sequentially delivering microcrystals to an X-ray beam to capture diffraction patterns, primarily using X-ray Free Electron Lasers (XFELs) and increasingly synchrotron experiments.
- This method allows for time-resolved studies without radiation damage to the crystals, enabling researchers to gather data over a vast range of time scales, from femtoseconds to seconds.
- The fixed target approach in this technique offers advantages such as maximizing crystal usage for data collection and precise control for timing experiments, with notable applications at the Diamond Light Source and SACLA XFEL.
Article Synopsis
- Schizophrenia (SCZ) shows differences in brain structure and symptoms between men and women, suggesting distinct neurobiological factors linked to sex.
- The study analyzed MRI data from nearly 6,000 participants to explore the effects of sex and diagnosis on the shape of deep brain regions in individuals with SCZ compared to healthy controls.
- Results indicated that women with SCZ had more pronounced shape abnormalities than men, but there were no significant interactions between diagnosis and sex, highlighting the need for further exploration of sex-related differences in schizophrenia's neurobiology.
Article Synopsis
- The study examined the national rate of emergency cesarean sections (ECS) in pregnant trauma patients (PTPs) who were involved in motor vehicle collisions (MVCs) and found that 8% underwent ECS.
- The median time from arrival to ECS was 115 minutes, with ECS patients showing higher rates of lung and spleen injuries, complications, and mortality compared to those who did not undergo ECS.
- Key risk factors for requiring ECS included severe head or abdominal injuries and an elevated shock index (SI), indicating the severity of injury.
Intermittent sigh breaths during high-frequency oscillatory ventilation in preterm infants: a randomised crossover study.
Arch Dis Child Fetal Neonatal Ed
October 2024
Objective: To determine if combining high-frequency oscillatory ventilation (HFOV) with additional sigh breaths would improve end-expiratory lung volume (EELV) and oxygenation in preterm infants.
Design: Prospective interventional crossover study.
Setting: Neonatal intensive care unit.
Copper nitrite reductases (CuNiRs) exhibit a strong pH dependence of their catalytic activity. Structural movies can be obtained by serially recording multiple structures (frames) from the same spot of a crystal using the MSOX serial crystallography approach. This method has been combined with on-line single crystal optical spectroscopy to capture the pH-dependent structural changes that accompany during turnover of CuNiRs from two Rhizobia species.
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