Publications by authors named "M Castillejo"

Analysis of glass-based artworks is important for authentication purposes. In recent years, there have been rapid advancements and improvements in the characterization of glass objects using different analytical approaches. The present study presents an interdisciplinary and multi-analytical authentication approach that provides useful tools and markers to unmask possible imitations, counterfeiting, and forgeries in Cultural Heritage glass beads by comparing the composition of historical and modern glass beads.

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  • Peanut production can be enhanced by using plant growth-promoting rhizobacteria (PGPR), with a field study showing an 8% increase in seed yield and improved radiation use efficiency (4-14%).
  • The use of PGPR resulted in significant changes in soil enzyme activity and microbial abundance, with dehydrogenase and fluorescein diacetate activities increasing by 28% and 17% respectively, but did not significantly affect microbial diversity.
  • PGPR altered the relative abundance of key microbial phyla and genera, and influenced genes related to nitrogen fixation, nitrification, and assimilation, ultimately benefiting peanut agronomy without changing rhizosphere diversity.
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  • DNA methylation plays a crucial role in plant growth and adaptability, yet it is under-researched in holm oak and other non-domesticated forest trees.
  • The study identified 13 DNA methyltransferase and 3 demethylase genes, with varying expression levels across different plant organs and developmental stages, showing that adult leaves have higher global DNA methylation levels.
  • Methylation patterns predominantly affected nuclear genes, particularly in regions associated with essential biological processes like photosynthesis and defense mechanisms, highlighting the importance of epigenetic variation in holm oak.
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Background: Treatment of castration-resistant metastatic prostate cancer with [¹⁷⁷Lu]PSMA radioligand.

Case Presentation: A man in his seventies with metastatic prostate cancer received castration therapy for four years, developing castration-resistant disease. PET/CT with [⁶⁸Ga]PSMA-11 showed high uptake in metastatic lymph nodes.

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  • Prostate-specific membrane antigen (PSMA) PET significantly enhances management decisions for patients with biochemically recurrent prostate cancer by revealing more positive findings compared to MRI and CT alone.
  • The study analyzed data from 41 patients, showing that the combination of PET with either MRI or CT led to improved detection rates and altered treatment plans for a considerable number of patients.
  • The interreader agreement improved significantly with the addition of PET, highlighting its importance in clinical assessment and decision-making.
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