Publications by authors named "M Carmen Ramirez-Tortosa"
Introduction: Chronic obstructive pulmonary disease (COPD) is one of the world's major public health problems. It is characterized by a major inflammatory response, where vitamin D, due to its role in regulating the immune system, and genetic variants involved in its metabolism may play an essential role. The aim of this study is to evaluate the association between 13 polymorphisms related to vitamin D metabolism and the COPD risk.
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- * The study reviewed the effects of 1CM-related nutrients on breast cancer and analyzed single nucleotide polymorphisms in genes related to 1CM, focusing on their significance in the Caucasian population.
- * Results indicate that B-complex vitamins from 1CM are crucial for preventing breast cancer and that associated genes are overexpressed in breast tissue, suggesting a need for further research on their interaction in cancer development.
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- - Methotrexate (MTX) is commonly used to treat moderate-to-severe psoriasis but can cause toxicity in some patients, leading to treatment suspension.
- - A study involving 101 patients identified specific genetic variations (SNPs) linked to an increased risk of developing adverse effects from MTX, including the rs2238476-AG and rs376154-GT genotypes.
- - The findings suggest these SNPs could serve as biomarkers to predict MTX toxicity in psoriasis patients, allowing for better management of treatment plans.
Several studies have suggested that single nucleotide polymorphisms (SNPs) related to vitamin D metabolism may affect CRC carcinogenesis and survival. The aim of this study was to evaluate the influence of 13 SNPs involved in the vitamin D metabolic pathway on CRC survival. We conducted an observational retrospective cohort study, which included 127 Caucasian CRC patient from the south of Spain.
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- Biological therapies for psoriasis are effective, but many patients experience reduced effectiveness, leading to treatment switches; this study examines how genetic variations may affect drug survival for anti-TNF and ustekinumab (UTK) therapies in patients.
- The study analyzed 379 treatment lines involving 206 patients, genotyping 29 SNPs to assess which genetic factors influence the effectiveness of these treatments using statistical methods.
- Results indicate specific SNPs are linked to better drug survival rates for both anti-TNF and UTK, suggesting that understanding these genetic markers could aid personalized treatment approaches and improve healthcare outcomes, although more research is needed to validate these findings.