Identification of cis-sQTL demonstrates genetic associations and functional implications of inflammatory processes in Nelore cattle muscle tissue.

This study aimed to identify splicing quantitative trait loci (cis-sQTL) in Nelore cattle muscle tissue and explore the involvement of spliced genes (sGenes) in immune system-related biological processes. Genotypic data from 80 intact male Nelore cattle were obtained using SNP-Chip technology, while RNA-Seq analysis was performed to measure gene expression levels, enabling the integration of genomic and transcriptomic datasets. The normalized expression levels of spliced transcripts were associated with single nucleotide polymorphisms (SNPs) through an analysis of variance using an additive linear model with the MatrixEQTL package.

Differentially expressed messenger RNA isoforms in beef cattle skeletal muscle with different fatty acid profiles.

This study aimed to identify mRNA isoforms that were expressed differently in the muscle tissue of Nellore cattle based on their intramuscular fatty acid profile. Forty-eight young bulls were used to quantify beef fatty acids (FA) and perform RNA sequencing analysis. The young bulls were divided into three different groups based on quantifying FA using k-means analysis.

Genu Varum Correction with HA Filler Volumisation of the Medial Gastrocnemius.

Background: Genu varum, or bow-legged deformity, involves an outward curvature of the lower limbs, often creating a visible gap between the knees when the ankles are together. Traditionally treated with invasive surgical methods like high tibial osteotomy, genu varum correction now includes less invasive options for patients with mild to moderate deformities. This commentary explores a novel approach using hyaluronic acid (HA) filler to volumise the medial gastrocnemius muscle, thereby improving calf contour and stability without surgery.

Treatment of the Temples: Brazilian Consensus.

Introduction: The temporal region is emblematic and challenging due to its structural and volumetric changes during aging, which significantly affect facial aesthetics. Despite the importance of addressing temporal aging, many injectors hesitate due to the region's anatomical complexity and risk of complications. This consensus aimed to provide expert guidance on the safest and most effective treatment strategies for the temple.