SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma.

End-stage liver disease is marked by portal hypertension, systemic elevations in ammonia, and development of hepatocellular carcinoma (HCC). While these clinical consequences of cirrhosis are well described, it remains poorly understood whether hepatic insufficiency and the accompanying elevations in ammonia contribute to HCC carcinogenesis. Using preclinical models, we discovered that ammonia entered the cell through the transporter SLC4A11 and served as a nitrogen source for amino acid and nucleotide biosynthesis.

CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus.

Background: Respiratory syncytial virus (RSV) causes significant morbidity and mortality in children aged ≤ 5 years and adults aged ≥ 60 years worldwide. Despite this, RSV-specific therapeutic options are limited. Rilematovir is an investigational, orally administered inhibitor of RSV fusion protein-mediated viral entry.

The Role and Versatility of the Temporoparietal Fascia Flap for Coverage of Cochlear Implant Extrusion.

The use of cochlear implants (CI) may be associated with different complications, being extrusion of the device one of the most common. Reconstruction of the defect with a healthy and vascularized tissue is often required. We present two patients with a CI extrusion treated with a temporoparietal fascia flap.

New perspectives on respiratory syncytial virus surveillance at the national level: lessons from the COVID-19 pandemic.

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