Publications by authors named "M Carley"
Article Synopsis
- Preclinical studies highlight the importance of glial cells in pain mechanisms, leading to a systematic review of human trials on glia-modulating drugs for pain treatment.
- The review included 26 trials with a total of 2,132 participants, focusing on the effects of drugs like minocycline and pentoxifylline, but found significant variability among studies and no conclusive evidence of effectiveness.
- Future research is encouraged to identify optimal glial-targeted drugs, the ideal timing and duration for their use, and improved designs for clinical trials to better assess their potential in pain management.
Background: Co-production is a collaborative approach to prepare, plan, conduct, and apply research with those who will use or be impacted by research (knowledge users). Our team of knowledge users and researchers sought to conduct and evaluate co-production of a systematic review on decision coaching.
Methods: We conducted a mixed-methods case study within a review to describe team co-production of a systematic review.
Background: When people who can use or benefit from research findings are engaged as partners on study teams, the quality and impact of findings are better. These people can include patients/consumers and clinicians who do not identify as researchers. They are referred to as "knowledge users".
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