Publications by authors named "M Cargnelutti"
Auditory Brainstem Response with the iChirp stimuli in the infant's audiological diagnosis.
Int J Pediatr Otorhinolaryngol
March 2022
Objective: to investigate the use of the iChirp stimulus in the infant's audiological diagnosis compared to stimuli typically used in the ABR in infants, in addition to suggesting reference values for the assessment of this population.
Methods: 62 infants participated in the study, 29 females and 33 males. The subjects underwent the recording of the Auditory Brainstem Response in the Smart Ep equipment, with the stimuli click, iChirp-broadband, tone burst and iChirp-narrowband, which were presented at three levels of intensity (20 dB, 40 dB and 60 dB) and, for tone burst and iChirp-narrowband stimuli, at different frequencies (0.
Article Synopsis
- Gastric cancer is the third leading cause of cancer deaths globally, and despite treatment advancements, patients with advanced stages have poor outcomes, highlighting the need for new therapeutic targets.
- Researchers developed a comprehensive platform of gastric cancer models, including 100 patient-derived xenografts (PDX), primary cell lines, and organoids, classified by various molecular and histological traits.
- Analysis of the PDX models revealed a specific microsatellite instability (MSI) signature that helps identify a subgroup of microsatellite stable (MSS) patients with better prognosis, suggesting new avenues for treatment and target validation.
Patient-Derived Xenografts (PDXs), entailing implantation of cancer specimens in immunocompromised mice, are emerging as a valuable translational model that could help validate biologically relevant targets and assist the clinical development of novel therapeutic strategies for gastric cancer. More than 30% of PDXs generated from gastric carcinoma samples developed human B-cell lymphomas instead of gastric cancer. These lymphomas were monoclonal, Epstein Barr Virus (EBV) positive, originated tumorigenic cell cultures and displayed a mutational burden and an expression profile distinct from gastric adenocarcinomas.
View Article and Find Full Text PDFAims: Atrial fibrillation (AF) is the leading rhythm disorder in western countries. A direct relationship between left atrium (LA) enlargement and electromechanical remodelling has been established. A causative link between epicardial fat (EF), visceral adipose tissue deposited around the heart, and AF has been hypothesized.
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