Empirical evidence for multi-decadal transients affecting geodetic velocity fields and derived seismicity forecasts in Italy.

This study critically examines the use of geodetic strain rates for forecasting long-term earthquake rates in a slow-deforming region such as Italy, challenging the prevailing assumption of their temporal stationarity in interseismic stages for seismic hazard analyses. Typically, earthquake-rate models derived from geodesy assume stationary interseismic loading rates, with stress rates in the upper crust proportional to geodetic strain rates, leading to earthquake rates directly proportional to these strain rate tensors. However, our analysis unveils a pronounced correlation between the epicenters of earthquakes that occurred in the past 60-120 years and areas forecasted for higher future earthquake rates based on geodetic strain rates.

Lentisk () Oil Nanoemulsions Loaded with Levofloxacin: Phytochemical Profiles and Antibiofilm Activity against spp.

Most clinical isolates of both and show the capacity to adhere to abiotic surfaces and to develop biofilms resulting in a contribution to chronic human skin infections. Antibiotic resistance and poor biofilm penetration are the main causes of ineffective therapeutic treatment in killing bacteria within biofilms. A possible strategy could be represented by drug delivery systems, such as nanoemulsions (composed of bioactive oil, surfactant and water phase), which are useful for enhancing the drug permeation of a loaded drug inside the biofilm and its activity.

Bioactive pH-sensitive nanoemulsion in melanoma cell lines.

Melanoma is an aggressive form of skin cancer with elevated propensity to metastasize. One of the major critical issues in the treatment of oncological patients is represented by the development of toxicity and resistance to the available therapies. Great progress has been made in the field of nanotechnologies to limit the unwanted effects of anti-cancer treatments.

Gentamicin loaded niosomes against intracellular uropathogenic Escherichia coli strains.

Urinary tract infections (UTIs) are the most common bacterial infections and uropathogenic Escherichia coli (UPEC) is the main etiological agent of UTIs. UPEC can persist in bladder cells protected by immunological defenses and antibiotics and intracellular behavior leads to difficulty in eradicating the infection. The aim of this paper is to design, prepare and characterize surfactant-based nanocarriers (niosomes) able to entrap antimicrobial drug and potentially to delivery and release antibiotics into UPEC-infected cells.