Using an Ensemble to Identify and Classify Macroalgae Antimicrobial Peptides.

The rapid spread of multi-drug resistant microbes has lead researchers to discover natural alternative remedies such as antimicrobial peptides (AMPs). In the first line of defense, AMPs display a broad spectrum of potent activity against multi-resistant pathogenic bacteria, viruses, fungi, and even cancer. AMPs can be further characterised into families according to amino acid composition, secondary structure, and function.

A patient with Edwards syndrome caused by a rare pseudodicentric chromosome 18 of paternal origin.

We present an unusual case of trisomy 18 due to a pseudodicentric chromosome 18 of paternal origin. The karyotype was: 46,XY, -18, +psu dic(18)(qter-->cen-->p11.31::p11.

Extreme variant of the short arm of chromosome 15.

Using fluorescence in situ hybridization, primed in situ labelling, and conventional cytogenetic staining we have characterized an excessively enlarged short arm of chromosome 15. The likely mechanism explaining this variant chromosome involves amplification of rDNA sequences followed by inverted insertional translocation between the enlarged sister chromatids of the short arm of chromosome 15.

Fluorescence in situ hybridization reveals a break in the alpha-satellite DNA of chromosome 1 in a family with a balanced whole-arm translocation.

We have characterized a whole-arm translocation involving chromosomes 1 and 19 by traditional cytogenetic methods and fluorescence in situ hybridization with chromosome-specific alpha-satellite and whole-chromosome painting probes, and different satellite III DNA probes. We have identified a break in the alpha-satellite DNA region of chromosome 1, with division of this material into two alpha-satellite DNA blocks. This leaves one translocation chromosome with truncated alpha-satellite DNA from chromosome 1 and the other translocation chromosome with all the alpha-satellite DNA from chromosome 19 and truncated alpha-satellite DNA from chromosome 1.

Breakpoints in Robertsonian translocations are localized to satellite III DNA by fluorescence in situ hybridization.

We characterized 21 t(13;14) and 3 t(14;21) Robertsonian translocations for the presence of DNA derived from the short arms of the translocated acrocentric chromosomes and identified their centromeres. Nineteen of these 24 translocation carriers were unrelated. Using centromeric alpha-repeat DNA as chromosome-specific probe, we found by in situ hybridization that all 24 translocation chromosomes were dicentric.