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Background: Cannabis is the most commonly used illicit substance in Ireland and globally. It is most likely to be used in adolescence, a period of biopsychosocial vulnerability to maladaptive behaviours. This study aims to investigate the risk and protective factors for cannabis use among adolescents.

Cannabis use in youth is associated with chronic inflammation.

Background: Markers of inflammation and cannabis exposure are associated with an increased risk of mental disorders. In the current study, we investigated associations between cannabis use and biomarkers of inflammation.

Methods: Utilizing a sample of 914 participants from the Avon Longitudinal Study of Parents and Children, we investigated whether interleukin-6 (IL-6), tumor necrosis factor (TNF), C-reactive protein (CRP), and soluble urokinase plasminogen activator receptor (suPAR) measured at age 24 were associated with past year daily cannabis use, less frequent cannabis use, and no past year cannabis use.

Plasma levels of matrix metalloproteinases in early psychosis, anxiety and depression: Evidence from the ALSPAC cohort.

Background: Converging evidence supports the role of Matrix Metalloproteinases (MMPs) in psychiatric disorders. Originally identified as regulators of the extracellular matrix (ECM), MMPs' functions span multiple processes, including inflammation, synaptic plasticity, neuronal migration, and blood-brain barrier maintenance. Tissue Inhibitors of Metalloproteinases (TIMPs) are major regulators of MMPs.

An evaluation of the Live Well Erie workforce development program, jumping off the benefits cliff: A protocol paper.

While research has suggested that addressing multiple needs simultaneously may increase the chances for positive labor force outcomes, few studies have explored a multi-pronged approach to assist individuals with jumping off the benefits cliff. The purpose of the current study is to explore the potential of a Career Pathway program designed to supplement benefits for those who "jump off the benefits cliff." This study will employ qualitative impact assessment protocol (QuIP) and observational methods to assess the implementation of the career pathway program through (1) observation, (2) focus groups with service providers and program stakeholders, and (3) semi-structured interviews with program participants.