Publications by authors named "M Cancelliere"

Article Synopsis
  • Asparaginase (ASNase) significantly improves treatment outcomes for pediatric Acute Lymphoblastic Leukemia (ALL), achieving remissions in about 90% of cases, but its effects on adult solid tumors are not well understood.
  • In a study on three adenocarcinoma cell lines (A549, MCF-7, and 786-O), it was found that A549 and 786-O cells responded differently to ASNase treatment, with A549 showing a typical response while 786-O displayed alterations in cell cycle phases and dysfunctional DNA synthesis.
  • The findings suggest unique mechanisms of ASNase action in solid tumors, particularly in the 786-O cells, indicating a different response than what is seen in leukemic
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A case of hypertensive endoventricular pneumocephalus associated with rhinoliquorrea raised after about 2 years from the application of ventriculo-peritoneal shunt for hydrocephalus by stenosis of aqueduct is presented. The causes of such complication and diagnostic possibilities to point out the fistula by CT and ventricular cisternography are to talk over. Even the indication of external CSF drainage or to the repairing treatment will be discussed.

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Oxygen free-radical reperfusion products play a critical role in postischemic tissues injury. In this study we used deferoxamine, an iron ligand that seems to inhibit hydroxyl radicals production, in renal normothermic acute ischemia in the rat. Our results demonstrated a significant protective effect of deferoxamine on kidneys subjected to normothermic acute ischemia.

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Renal angiomyolipoma is a benign tumor that can be observed in two distinct types: the solitary type and the tuberous sclerosis associated type. It is now diagnosed, even if asymptomatic, with increasing frequency by means of ultrasonography and computerized tomography owing to its particular features. The possibility of preoperative diagnosis and the biological characteristics of this benign lesion should induce a more conservative management.

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The authors report their own experience on the efficacy of a short term antimicrobial prophylaxis involving a long-acting cephalosporin, ceftriaxone (Rocefin), in surgical patients. A study was carried out to evaluate the efficacy of a single dose of 1 or 2 g by i.v.

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