Publications by authors named "M Campagnolo"
In this study, we compared the value of pathological alpha-synuclein (αSyn) seed amplification assay (SAA) in gastric and duodenal biopsies with skin biopsies in Parkinson disease (PD) patients with different disease duration. The accuracy of αSyn SAA was 87.7% in skin, 67.
View Article and Find Full Text PDFIn Parkinson's disease, neuroinflammation is a double-edged sword; when inflammation occurs it can have harmful effects, despite its important role in battling infections and healing tissue. Once triggered by microglia, astrocytes acquire a reactive state and shift from supporting the survival of neurons to causing their destruction. Activated microglia and Proteinase-activated receptor-2 (PAR2) are key points in the regulation of neuroinflammation.
View Article and Find Full Text PDFBackground: Gastrointestinal dysfunction has emerged as a prominent early feature of Parkinson's Disease, shedding new light on the pivotal role of the enteric nervous system in its pathophysiology. However, the role of immune-cell clusters and inflammatory and glial markers in the gut pathogenetic process needs further elucidation.
Objectives: We aimed to study duodenum tissue samples to characterize PD's enteric nervous system pathology further.
Article Synopsis
- Parkinson's disease (PD) is a complex disorder influenced by genetic factors, with this study focusing on a cohort from Northeastern Italy to explore its genetic basis and clinical characteristics.
- Using a next-generation sequencing (NGS) panel, researchers identified 133 genetic variants in 218 PD patients, diagnosing monogenic PD in 20% of them, primarily linked to mutations in the GBA1, LRRK2, and PRKN genes.
- The findings suggest that certain clinical criteria, like early age of onset, can reliably predict positive genetic test outcomes, which helps in managing patient care and opens avenues for future therapies targeting specific genetic causes of the disease.
Chikungunya fever (CF) is caused by an arbovirus whose manifestations are extremely diverse, and it has evolved with significant severity in recent years. The clinical signs triggered by the Chikungunya virus are similar to those of other arboviruses. Generally, fever starts abruptly and reaches high levels, followed by severe polyarthralgia and myalgia, as well as an erythematous or petechial maculopapular rash, varying in severity and extent.
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