Background: The microbiota-derived short chain fatty acid butyrate has been shown to lower blood pressure (BP) in rodent studies. Nonetheless, the net effect of butyrate on hypertension in humans remains uncovered. In this study, for the first time, we aimed to determine the effect of oral butyrate on BP in patients with hypertension.
View Article and Find Full Text PDFHome and ambulatory blood pressure (BP) better predict cardiovascular disease than office BP, but are not interchangeable. We hypothesised that home BP may be higher than office BP because of anticipatory reactions to self-measurement and studied prevalence and reproducibility of incremental differences between home and daytime ambulatory BP and their relation with hypertensive organ damage. A total of 176 participants (mean age 57.
View Article and Find Full Text PDFBackground: The vasodilating beta-blocker nebivolol is thought to be superior in lowering wave reflection and central blood pressure (BP) compared to nonvasodilating beta-blockers. The results from studies comparing nebivolol with either metoprolol or atenolol, with or without hydrochlorothiazide (HCTZ), are not unequivocal.
Methods: We examined the effects of nebivolol 5 mg and metoprolol 100 mg with HCTZ 12.
Background: The accuracy of home blood pressure measurement (HBPM) depends on adherence to the measurement schedule. We investigated the number of deviations from the requested schedule using an HBPM device equipped with a diagnostic mode that only allows patients to take a fixed number of BP readings at preset times.
Methods: We randomized patients to measure their BP as recommended by the European Society of Hypertension guideline in either the usual mode or the diagnostic mode.