Prospective, randomized, double-blind study of safety and tolerability of intravesical resiniferatoxin (RTX) in interstitial cystitis (IC).

Objective: To determine the safety and tolerability of intravesical resiniferatoxin (RTX) in interstitial cystitis (IC) patients.

Materials And Methods: IC patients were instilled with 50 cc of test solution containing either placebo, 0.05 microM or 0.

Cluster headache as a manifestation of intracranial inflammatory myofibroblastic tumour: a case report with pathophysiological considerations.

We report a patient with a secondary form of chronic cluster headache, caused by an intracranial presentation of inflammatory myofibroblastic pseudotumour located in the posterior fossa, with total remission of the pain after resection. The headaches were resistant to many of the usual treatments for cluster headache. The patient had two normal computed tomography scans and one normal magnetic resonance imaging of the head before the additional diagnosis of brain tumour was made.

Twist-drill craniostomy for the treatment of chronic subdural hematoma.

The choice of the initial surgical method for treating the patient with CSH is influenced by the patient's neurologic status at the time of presentation, associated medical factors, and the surgeon's experience in the management of these patients. The outcome data suggest that twist-drill craniostomy with closed-system catheter drainage results in an equivalent or superior outcome to the historical results of craniotomy with membranectomy. Craniotomy remains the treatment of choice when the admitting computerized tomographic scan demonstrates a significant hyperdense component suggesting the presence of solid or mixed hematoma.

Mutagenesis and chimeric genes define determinants in the beta subunits of human chorionic gonadotropin and lutropin for secretion and assembly.

Chorionic gonadotropin (CG) and lutropin (LH) are members of a family of glycoprotein hormones that share a common alpha subunit but differ in their hormone-specific beta subunits. The glycoprotein hormone beta subunits share a high degree of amino acid homology that is most evident for the LH beta and CG beta subunits having greater than 80% sequence similarity. However, transfection studies have shown that human CG beta and alpha can be secreted as monomers and can combine efficiently to form dimer, whereas secretion and assembly of human LH beta is less efficient.