Publications by authors named "M Calvez"
Article Synopsis
- There is a lack of research on psychiatric emergencies in older adults over 60, especially in Europe, prompting a study at a major French psychiatric emergency center.
- The study involved 300 older patients, predominantly women, many with a history of psychiatric issues, commonly presenting with depression, anxiety, and suicidal thoughts.
- Findings indicated that 39% of these patients were hospitalized, with factors like past hospitalizations, suicidal tendencies, and certain psychiatric diagnoses being key predictors of hospitalization.
The sexual life of elderly people living in residential institutions for the dependent elderly (Ehpad) is a sensitive subject that is rarely discussed. Particular difficulties sometimes arise when they have cognitive problems. Affectivity and sexuality in old people's homes must be approached with tact and maturity by the carers.
View Article and Find Full Text PDFBiliary diseases are the third most common cause of surgical digestive disease. There is a close relationship between the mechanical performance of the bile duct and its physiological function. Data of biomechanical properties of human main bile duct are scarce in literature.
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- HIV-1 does not infect neurons directly but affects brain glial cells, leading to neurotoxicity and inflammation that harm neurons despite antiretroviral treatment.
- Osteopontin (OPN), a proinflammatory protein, is elevated in the brains of those with HIV-associated cognitive disorders, but its effects on neuronal function are not well understood.
- This study reveals that OPN interacts with HIV's envelope protein and activates the mTOR pathway in neurons, impacting their structure and potentially influencing cognitive dysfunction in HIV-infected individuals.*
Cystic fibrosis (CF) is the most common autosomal recessive disease in Caucasians caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) chloride (Cl-) channel regulated by protein kinases, phosphatases, divalent cations and by protein-protein interactions. Among protein-protein interactions, we previously showed that Annexin A5 (AnxA5) binds to CFTR and is involved in the channel localization within membranes and in its Cl- channel function. The deletion of phenylalanine at position 508 (F508del) is the most common mutation in CF which leads to an altered protein (F508del-CFTR) folding with a nascent protein retained within the ER and is quickly degraded.
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