Publications by authors named "M Calvano"

Background: Cocaine overdose is a condition in which an increase in blood pressure, heart rate and depth of breath is observed. Cocaine consumption also causes a wide and well-known neuropsychiatric symptomatology that is characterized by incomprehensible behavior, confused and disordered thoughts, and paranoia. Cocaine addiction is a worldwide public health problem, which has somatic, psychological, psychiatric, socio-economic, and judicial complications.

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Bones and teeth represent a common finding in ancient DNA studies and in forensic casework, even after a long burial. Genetic typing is the gold standard for the personal identification of skeletal remains, but there are two main factors involved in the successful DNA typing of such samples: (1) the set-up of an efficient DNA extraction method; (2) the identification of the most suitable skeletal element for the downstream genetic analyses. In this paper, a protocol based on the processing of 0.

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The interpretation of tanatochronological data is a fundamental aspect of the medico legal diagnosis, because it allows to trace back the interval of death. Traditionally, the evaluation of the hypostasis plays a relevant role in the interpretation of such information, despite its well-known limits and fallacies. In order to evaluate the degree of hypostatic area discoloration, the methodology currently used is highly subjective and influenced by several variables.

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Article Synopsis
  • Alzheimer's disease (AD) is characterized by protein aggregates, inflammation, and issues with blood vessels, including a damaged blood-brain barrier that allows harmful proteins like fibrinogen to enter the brain.
  • Fibrinogen interacts negatively with amyloid-beta (Aβ) peptides, worsening blood flow and clotting issues associated with AD.
  • Lecanemab, an FDA-approved treatment for AD, helps remove Aβ plaques and prevents negative interactions between Aβ and fibrinogen, potentially slowing disease progression.
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