Differential Effects of Tra2ß Isoforms on HIV-1 RNA Processing and Expression.

Balanced processing of HIV-1 RNA is critical to virus replication and is regulated by host factors. In this report, we demonstrate that overexpression of either Tra2α or Tra2β results in a marked reduction in HIV-1 Gag/Env expression, an effect associated with changes in HIV-1 RNA accumulation, altered viral splice site usage, and a block to export of HIV-1 genomic RNA. A natural isoform of Tra2β (Tra2ß3), lacking the N-terminal RS domain, also suppressed HIV-1 expression but had different effects on viral RNA processing.

Radiology case of the month. Abnormal bone survey in a cancer patient. Osteopoikilosis.

A 34-year-old woman presented with a history of thyroid carcinoma who underwent a radiographic bone survey in search of metastatic disease.