Publications by authors named "M Calaminici"
Article Synopsis
- In follicular lymphoma (FL), doctors have trouble finding the best treatment because different patients have different types of the disease, except for one drug that helps some patients with a specific gene change.
- Researchers studied 21 patients with FL who were not getting better and were treated with two different drugs, everolimus and temsirolimus, to see how their gene changes affected treatment success.
- They found that patients who responded well to the drugs had more changes in a specific gene called CREBBP, suggesting that this gene can help predict which treatments might work better for FL patients.
Article Synopsis
- The REFRACT trial is a UK-based clinical trial aimed at improving treatments for relapsed or refractory follicular lymphoma (rrFL) by testing a new combination therapy of epcoritamab and lenalidomide against standard treatment options.
- Eligible participants are adults with specific types of follicular lymphoma, and the trial's main goal is to assess the effectiveness of the new therapy based on complete metabolic response as measured by PET-CT after 24 weeks.
- The study aims to fill the gap in understanding the safety and efficacy of novel therapies in comparison to existing standards, using a unique design to streamline the process and reduce the number of patients needed for reliable results.
Correction: "The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms" Leukemia. 2022 Jul;36(7):1720-1748.
Rita Alaggio Catalina Amador Ioannis Anagnostopoulos Ayoma D Attygalle Iguaracyra Barreto de Oliveira Araujo Mariarita Calaminici
Leukemia
September 2023
Article Synopsis
- The Sydney system was developed to improve standardization and reproducibility in lymph node cytopathology, with previous studies focusing on its risk of malignancy but not on how consistently different pathologists can interpret it.
- A study involving 15 cytopathologists from 12 institutions globally evaluated 85 cases using digital whole-slide images, resulting in over 1200 diagnoses.
- The findings indicated nearly perfect agreement with a ground truth for most diagnoses, but varying levels of concordance across categories, with the inadequate and malignant categories showing the most agreement, while suspicious and atypical categories had very slight agreement.