Publications by authors named "M CORNU"
The disruption of proteostasis provides a favourable context for the emergence of therapeutic innovations, in particular by exploiting technologies such as the PROTAC (Proteolysis Targeting Chimera) approach. These technologies aim to selectively target proteins involved in various diseases, including cancer and neurodegenerative diseases, by inducing their specific degradation via the ubiquitin-proteasome system. The PROTAC approach opens new opportunities for restoring altered protein homeostasis and modulating the pathological consequences of proteostasis deregulation.
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- The study aimed to standardize qPCR procedures for diagnosing Mucorales by examining factors that influence DNA extraction and PCR amplification efficiency.
- Two panels of samples were distributed to 26 laboratories, and results showed that using larger serum volumes for DNA extraction and larger input volumes for PCR significantly improved detection sensitivity.
- Findings highlight the importance of optimizing laboratory techniques to enhance diagnosis of Mucormycosis, a serious fungal infection, which is critical for timely treatment in vulnerable patients.
This study investigates the diagnostic practices for mucormycosis among 30 French University Hospital mycology laboratories, in 2024. All laboratories perform both direct examination and culture, with fluorescent brighteners being the most commonly used method for direct examination. While 77 % of the participating laboratories routinely identify Mucorales to the species level, with 70 % having adopted Mucorales-specific quantitative PCR, primarily for the diagnosis of invasive fungal infections.
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- XIAP is a protein that helps regulate cell survival and inflammation, and targeting it could benefit diseases like Crohn's disease and sarcoidosis.
- Researchers developed selective inhibitors for a specific part of XIAP (XIAP-BIR2) to disrupt its interaction with RIPK2, which is relevant to inflammatory diseases.
- They created a library of small synthetic molecules, identifying compound 20c, which effectively blocks the NOD1/2 signaling pathway in cells and holds potential as an anti-inflammatory treatment.
Hantaviruses, members of the Bunyaviridae family, can cause two patterns of disease in humans, hantavirus hemorrhagic fever with renal syndrome (HFRS) and cardiopulmonary syndrome (HCPS), being the latter hegemonic on the American continent. Andesvirus is one of the strains that can cause HCPS and is endemic in Chile. Its transmission occurs through direct or indirect contact with infected rodents' urine, saliva, or feces and inhalation of aerosol particles containing the virus.
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