Publications by authors named "M C Vitale"
Objectives: Concurrence of pregnancy and cancer diagnosis is increasingly frequent in Italy. The study aimed to compare women with pregnancy-associated cancers (PACs) to those of childbearing age, focusing on fertility, induced abortion, and miscarriage.
Methods: The population-based study included women aged 15-49 years, both with and without PAC, who were residents in the area covered by the 19 participating Cancer Registries between 2003 and 2015 and identified by individual deterministic linkage with the Hospital Discharge Database.
Background: The postprandial glucose response (PPGR), contributing to the glycemic variability (GV), is positively associated with cardiovascular disease risk in people without diabetes, and can thus represent a target for cardiometabolic prevention strategies.
Objectives: The study aimed to distinguish patterns of PPGR after a single nonstandardized meal and to evaluate their relationship with the habitual diet and the daily glucose profile (DGP) in individuals at high-cardiometabolic risk.
Methods: Baseline 4-d continuous glucose monitoring was performed in 159 adults recruited in the MEDGI-Carb trial.
Article Synopsis
- Isolation mechanisms in the Anopheles gambiae complex, important malaria vectors, include both pre-zygotic barriers reducing gene flow and post-zygotic issues like sterility in hybrid males and decreased fertility in hybrid females.
- Genetic studies have revealed that hybrid incompatibility is largely influenced by interactions on the X chromosome, while also noting differences in the fertility of hybrid males based on the direction of the cross.
- A study exploring the roles of mitochondrial DNA in hybrid incompatibilities found that switching mitochondrial DNA between species did not improve hybrid male fertility, suggesting it may not significantly contribute to these incompatibilities.
We previously demonstrated that patients with metastatic unresectable stage IIIb-IV melanoma receiving cetirizine (a second-generation H1 antagonist antihistamine) premedication with immunotherapy had better outcomes than those not receiving cetirizine. In this retrospective study, we searched for a gene signature potentially predictive of the response to the addition of cetirizine to checkpoint inhibition (nivolumab or pembrolizumab with or without previous ipilimumab). Transcriptomic analysis showed that inducible T cell costimulator ligand (ICOSLG) expression directly correlated with the disease control rate (DCR) when detected with a loading value > 0.
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