Publications by authors named "M C Varricchio"
Background: Telomeres maintain chromosome stability, while telomerase counteracts their progressive shortening. Telomere length varies between cell types, with leukocyte telomere length (LTL) decreasing with age. Reduced telomerase activity has been linked to reproductive issues in females, such as low pregnancy rates and premature ovarian failure, with recent studies indicating correlations between telomere length in granulosa cells and IVF outcomes.
View Article and Find Full Text PDFStudy Question: Can anti-Müllerian hormone (AMH) help predict how many oocytes will be retrieved following double stimulation (DuoStim)?
Summary Answer: A simple clinical tool can use serum AMH values to predict ovarian response following DuoStim in IVF cycles.
What Is Already Known: The knowledge that multiple follicular waves arise during a single ovarian cycle has led to the introduction of unconventional ovarian stimulation protocols. The DuoStim protocol involves two successive ovarian stimulations performed during a single ovarian cycle and has been proposed as an approach for patients with poor ovarian response and for medical fertility preservation.
Article Synopsis
- The study investigates the cytotoxic effects of ethanol extract from the aerial parts of a plant, traditionally used in Brazil for treating diseases, on gastric adenocarcinoma cells (AGS), as well as its chemical composition.
- Hexane and aqueous fractions of the extract displayed higher cytotoxicity against AGS cells, indicating potential effectiveness in cancer treatment.
- Key compounds identified include triterpenes like euphol and friedelin in the hexane fraction, and ellagic acid as the main phenolic compound in the aqueous extract, which are believed to contribute to the extract's antiproliferative effects against cancer cells.
Research Question: Which factors influence the success rate of egg donation programmes with imported vitrified oocytes?
Design: Observational longitudinal cohort study of 431 oocyte donation cycles conducted between January 2015 and February 2019. A total of 398 couples underwent an IVF cycle with imported donated vitrified eggs. All consecutive oocyte donation cycles conducted at the Centre for Reproductive Medicine of the European Hospital in Rome, Italy, were included.
Purpose: The need for protective measures during the COVID-19 pandemic forced assisted reproduction centers to adopt new protocols in order to reduce the risk of infection for patients and staff. A COVID-19 Compliant IVF ( fertilization) program based on the use of follitropin delta to induce ovarian stimulation and fixed protocol with GnRH (Gonadotropin-Releasing Hormone) antagonists was applied to demonstrate the efficacy of this program in reducing the necessity of patients to be present within the clinic while maintaining the expected success rate.
Methods: The program was applied to 100 patients (women aged between 20 and 40 years, at their first IVF cycle): pretreatment assessment was carried out video conference and clinical documentations were sent by email.