Publications by authors named "M C Szabo"
Plasma transfusions in neonatal intensive care units: a prospective observational study.
Arch Dis Child Fetal Neonatal Ed
January 2025
Objective: Despite lack of evidence supporting efficacy, prophylactic fresh frozen plasma and Octaplas transfusions may be administered to very preterm infants to reduce bleeding risk. International variation in plasma transfusion practices in neonatal intensive care units (NICUs) is poorly understood, therefore, we aimed to describe neonatal plasma transfusion practice in Europe.
Design: Prospective observational study.
Background: Minimizing the duration of mechanical ventilation is one of the most important therapeutic goals during the care of preterm infants at neonatal intensive care units (NICUs). The rate of extubation failure among preterm infants is between 16% and 40% worldwide. Numerous studies have been conducted on the assessment of extubation suitability, the optimal choice of respiratory support around extubation, and the effectiveness of medical interventions.
View Article and Find Full Text PDFImportance: Intraventricular hemorrhage (IVH) has been described to typically occur during the early hours of life (HOL); however, the exact time of onset is still unknown.
Objective: To investigate the temporal distribution of IVH reported in very preterm neonates.
Data Sources: PubMed, Embase, Cochrane Library, and Web of Science were searched on May 9, 2024.
Introduction: Cariprazine (CAR) is a potent dopamine receptor partial agonist antipsychotic approved by the EMA and the FDA. To address the uncertainty regarding the effectiveness of hormonal contraceptives during CAR co-administration and whether a second barrier method is necessary, a drug-drug interaction study with an oral contraceptive was conducted post-approval.
Methods: The phase I, fixed-sequence multicenter study involved two periods with 24 patients with schizophrenia, aiming to evaluate the effect of CAR on the pharmacokinetics (PK) of a combined oral contraceptive (COC) containing 30 μg ethinylestradiol (EE) and 150 μg levonorgestrel (LNG).
Article Synopsis
- Platelet transfusions are given to preterm infants to prevent bleeding, but recent studies showed higher risks of mortality and major bleeding with transfusions at a higher platelet count threshold of 50 × 10/L compared to 25 × 10/L.
- A prospective observational study across 64 neonatal intensive care units in 22 European countries was conducted to assess current platelet transfusion practices, which included tracking transfusion rates, indications, and patient outcomes.
- The findings indicated that the lower transfusion threshold of 25 × 10/L is being adopted in practice, though there's considerable variation in transfusion volumes and rates, highlighting the need for further research to optimize these practices.