Hyperuricemia Is Associated With Higher Mortality in Non-diabetic Heart Failure Patients.

Introduction: Hyperuricemia (HU) is associated with an increased risk of incident heart failure (HF) and adverse HF outcomes. Patients with diabetes mellitus (DM) have a greater prevalence of HU.

Aims: We evaluated the prognostic impact of HU in patients with HF according to the coexistence of DM.

Immunomodulatory Effects of Pterocarpanquinone LQB-118 in Murine Peritoneal Macrophages.

Background: Phagocytosis is an important function of macrophages. However, when it's dysregulated, it could compromise homeostasis. Thus, this study aimed to assess the inhibitory activity of pterocarpanquinone LQB 118 on murine macrophage phagocytosis.

Survey of parasitic fauna data from wild animals through coproparasitological diagnosis in Southern Brazil.

Background: The proximity between people and their domestic animals with wild animal populations can result in the spread of diseases with a significant impact on public health. Infection by parasites in wildlife is considered an important bioindicator of the current state of ecosystems, and studying the epidemiology of these infections is essential for a better understanding of natural foci. However, research on parasites in southern Brazil, especially in Rio Grande do Sul (RS), is considered incipient.

Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants.

Background: Adoptive transfer of autologous regulatory T cells (Tregs) is a promising therapeutic strategy aimed at enabling immunosuppression minimization following kidney transplantation. In our phase 1 clinical trial of Treg therapy in living donor renal transplantation, the ONE Study (ClinicalTrials.gov: NCT02129881), we observed focal lymphocytic infiltrates in protocol kidney transplant biopsies that are not regularly seen in biopsies of patients receiving standard immunosuppression.

A comparative study of Venezuelan immigrants' pre- and post-migration concerns for their children in the United States and Colombia.

Research suggests that forced migration may lead to cultural stress and psychological distress. However, little is known about immigrant parents' pre- and post-migration concerns for their children's welfare. The present study examined the concerns of Venezuelan parents who migrated to the United States versus those who migrated to Colombia, and whether post-migration concerns were related to cultural stressors, mental health, and cultural identity.