Publications by authors named "M C Shibu"
Article Synopsis
- * The study investigated the potential protective effects of water-extracted Artemisia argyi (AA) on heart cells (H9c2) exposed to DOX, focusing on specific cellular signaling pathways (IGF-IIR/Drp1/GATA4).
- * Results indicated that AA extract not only reduced damage caused by DOX but also mitigated symptoms of cardiac toxicity, suggesting it could be a promising option to protect the heart during cancer treatment.
Article Synopsis
- - The study investigates how a combination of Alpinate Oxyphyllae Fructus (AOF) and adipose-derived mesenchymal stem cells (ADMSCs) can help combat age-related kidney changes that may lead to chronic kidney disease in elderly rats.
- - Results indicate that this co-treatment improves kidney structure and function by reducing inflammation and oxidative stress, as well as protecting kidney cells from death caused by D-galactose.
- - Overall, this research suggests that AOF and ADMSC could provide a promising strategy for developing new treatments to manage kidney issues related to aging.
The most effective drug, doxorubicin (DOX), is widely used worldwide for clinical application as an anticancer drug. DOX-induced cytotoxicity is characterized by mitochondrial dysfunction. There is no alternative treatment against DOX-induced cardiac damage despite intensive research in the present decades.
View Article and Find Full Text PDFStem cells exhibit pluripotency and self-renewal abilities. Adipose-derived mesenchymal stem cells can potentially be used to reconstruct various tissues. They possess significant versatility and alleviate various aging-related diseases.
View Article and Find Full Text PDFTraditional Chinese medicine (TCM) has gained considerable attention over the past few years for its multicomponent, multitarget, and multi-pathway approach to treating different diseases. Studies have shown that TCMs as adjuvant therapy along with conventional treatment may benefit in safely treating various disorders. However, investigations on finding effective herbal combinations are ongoing.
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