Case Report: Persistent toxic reactions in a toddler with a negative blood cantharidin toxicology test.

Cantharidin is a potent natural toxin and has been used in traditional Chinese medicine to treat cancers and various ailments such as rabies or psoriasis. However, improper use of cantharidin can easily lead to poisoning. Despite there is an increasing amount of literature on the toxic mechanisms of cantharidin, there is still limited knowledge about the disease progression, toxic reactions and toxic blood concentrations in children with cantharidin poisoning.

Group psychological counseling-based growth mindset intervention to promote active aging behaviors in older people: protocol for a randomized controlled trial.

Background: Although active aging is widely accepted and applied in various countries, research on active aging has predominantly focused on environmental interventions, often overlooking the autonomy of older people. This study addresses this gap by using group psychological counseling technique to implement growth mindset interventions, aiming to stimulate older people's autonomy and foster their active aging behaviors.

Methods: This study employs a randomized controlled trial design with two groups: an autonomous intervention group and a usual control group.

Efficient Biosynthesis of Sialyllacto--tetraose a by a Metabolically Engineered BL21(DE3) Strain.

Recently, the construction of metabolically engineered strains for the microbial synthesis of human milk oligosaccharides (HMOs) has attracted increasing attention. However, fewer efforts were made in the in vivo biosynthesis of complex HMOs, especially sialylated complex HMOs. In this study, we engineered BL21(DE3) to efficiently produce sialyllacto--tetraose a (LST-a) efficiently.

Decreased stability of soil dissolved organic matter under disturbance of periodic flooding and drying in reservoir drawdown area.

Dissolved organic matter (DOM) constitutes the largest active carbon pool on earth, playing a crucial role in numerous biogeochemical processes. Understanding the molecular characteristics and chemical properties of DOM is essential for comprehending the global carbon cycle. However, there is a lack of systematic understanding regarding the influence of periodic flooding and drying, caused by reservoir operations, on the sources, characteristics and stability of soil DOM in the drawdown area, as well as the biotic and abiotic processes regulating DOM changes.

STING mediates increased self-renewal and lineage skewing in DNMT3A-mutated hematopoietic stem/progenitor cells.

Somatic mutations in DNA methyltransferase 3 A (DNMT3A) are frequently observed in patients with hematological malignancies. Hematopoietic stem/progenitor cells (HSPCs) with mutated DNMT3A demonstrate increased self-renewal activity and skewed lineage differentiation. However, the molecular mechanisms underlying these changes remain largely unexplored.