Publications by authors named "M C Sanchez-Quevedo"
Article Synopsis
- The study investigates the histological characteristics of parakeratinized (POM) and orthokeratinized (OOM) human oral mucosa, which is important for understanding periodontal diseases.
- Using advanced microscopy techniques, researchers found that POM has a thicker epithelial layer, specifically in the stratum spinosum, compared to OOM, which also shows differences in key protein expressions like CK10 and filaggrin.
- These findings enhance our knowledge of the oral mucosa's structure, potentially aiding in the treatment of related pathologies and advancing tissue engineering methods.
The embryonic development of the human umbilical cord (hUC) is complex, and different regions can be identified in this structure. The aim of this work is to characterize the hUC at in situ and ex vivo levels to stablish their potential use in vascular regeneration. Human umbilical cords were obtained and histologically prepared for in the situ analysis of four hUC regions (intervascular-IV, perivascular-PV, subaminoblastic-SAM, and Wharton's jelly-WH), and primary cell cultures of mesenchymal stem cells (hUC-MSC) isolated from each region were obtained.
View Article and Find Full Text PDFObjective: The aim of this study was to generate novel models of bioartificial human oral mucosa with increased vascularization potential for future use as an advanced therapies medicinal product, by using different vascular and mesenchymal stem cell sources.
Background: Oral mucosa substitutes could contribute to the clinical treatment of complex diseases affecting the oral cavity. Although several models of artificial oral mucosa have been described, biointegration is a major issue that could be favored by the generation of novel substitutes with increased vascularization potential once grafted in vivo.
Several models of bioartificial human urothelial mucosa (UM) have been described recently. In this study, we generated novel tubularized UM substitutes using alternative sources of cells. Nanostructured fibrin-agarose biomaterials containing fibroblasts isolated from the human ureter were used as stroma substitutes.
View Article and Find Full Text PDFErratum: Blanco-Elices, C. et al. In Vitro Generation of Novel Functionalized Biomaterials for Use in Oral and Dental Regenerative Medicine Applications. Running Title: Fibrin-Agarose Functionalized Scaffolds. 2020, , 1692.
Materials (Basel)
November 2020
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