Genetic and epigenetic characterization of sarcoma stem cells across subtypes identifies EZH2 as a therapeutic target.

High-grade soft tissue sarcomas (STS) are a heterogeneous and aggressive set of cancers. Failure to respond anthracycline chemotherapy, standard first-line treatment, is associated with poor outcomes. We investigated the contribution of STS cancer stem cells (STS-CSCs) to doxorubicin resistance.

Transtracheal Ultrasound as a Preventive Tool for ETT Related Adverse Events and Malpositioning in the ICU.

Introduction: Endotracheal tube (ETT) malpositioning can result in a myriad of complications. Daily chest radiographs (CXR) is the gold standard in monitoring these complications. Point-of-care transtracheal ultrasound (TTUS) is an emerging imaging modality for ETT positioning.

Sustainable Multi-Cycle Physical Recycling of Expanded Polystyrene Waste for Direct Ink Write 3D Printing and Casting: Analysis of Mechanical Properties.

This work investigates the sustainable reuse of expanded polystyrene (EPS) waste through a multi-cycle physical recycling process involving dissolution in acetone and subsequent manufacturing via Direct Ink Write (DIW) 3D printing and casting. Morphology and mechanical properties were evaluated as a function of the manufacturing technique and number of dissolution cycles. Morphological analysis revealed that casted specimens better replicated the target geometry, while voids in 3D-printed specimens aligned with the printing direction due to rapid solvent evaporation.

Linking tumor immune infiltration to enhanced longevity in recurrence-free breast cancer.

Background: The infiltration of tumor-infiltrating B cells and plasma cells in early-stage breast cancer has been associated with a reduced risk of distant metastasis. However, the influence of B-cell tumor infiltration on overall patient survival remains unclear.

Materials And Methods: This study explored the relationship between an antitumor immune response, measured by a 14-gene B-cell/immunoglobulin (IGG) signature, and mortality risk in 9638 breast cancer patients across three datasets.