Publications by authors named "M C Safir"
Purpose: To examine the safety and efficacy of combined treatment with topical ivermectin 1% and intense pulsed light (IPL) for dry eye disease (DED) secondary to demodex blepharitis.
Methods: A retrospective review of medical files of patients treated at a private clinic specializing in DED between November 2022 and February 2024 was performed. Sixty-one patients aged 18 years or older with DED because of demodex blepharitis, who received the IPL and ivermectin 1% combination therapy, were included.
Population pharmacokinetic analyses for sulbactam-durlobactam using Phase 1, 2, and 3 data.
Antimicrob Agents Chemother
November 2024
Article Synopsis
- Sulbactam-durlobactam is a newly approved combination drug for treating specific types of pneumonia in adults, using data from multiple clinical studies to assess its pharmacokinetics.
- A complex four-compartment model was created to understand how the drug behaves in the body, factoring in both kidney and non-kidney clearance methods.
- Key findings showed that factors like body weight and renal function impact drug clearance, with the model being suitable for predicting how the drug performs in different patient populations.
Reasons for Re-treatment Following Monovision Laser Refractive Surgery.
J Refract Surg
November 2024
Purpose: To assess the incidence and causes for re-treatment following monovision laser refractive surgery in a large data study spanning a decade.
Methods: The setting for this retrospective comparative study was Care Vision Laser Center, Tel Aviv, Israel. This study included patients aged 36 to 60 years who underwent monovision laser vision correction at the Care Vision Laser Centers, Israel, from January 2012 to December 2022.
Myopia and systemic manifestation of tissue hyperlaxity: A population-based cross-sectional study.
Clin Exp Ophthalmol
October 2024
Article Synopsis
- The study explored whether non-syndromic connective tissue hyperlaxity is linked to myopia in adolescents, using conditions like hernias and scoliosis as indicators of tissue hyperlaxity.
- Over 920,000 adolescents were analyzed, with 31.6% diagnosed with myopia; those with myopia exhibited higher rates of hernias (2.76%), pes planus (14.92%), and scoliosis (9.14%) compared to non-myopic peers.
- Findings suggest that myopic adolescents may have a greater tendency toward conditions associated with tissue laxity, indicating a possible systemic link between myopia and hyperlaxity.
Purpose: To identify factors predicting slow visual recovery following myopic microkeratome assisted in situ keratomileusis (LASIK).
Design: Retrospective study.
Methods: This study included consecutive patients who underwent microkeratome-assisted myopic LASIK between January 2005 and December 2019 at Care Vision Laser Center, Tel Aviv, Israel.