Publications by authors named "M C Sadler"
Background: Neutrophil-to-lymphocyte ratio (NLR) is an easy-to-use inflammatory biomarker. Baseline NLR is independently associated with incident cardiovascular events and all-cause mortality. However, whether this applies to acute myocarditis (AM) has not been evaluated.
View Article and Find Full Text PDFAdverse drug responses (ADRs) result in over 7,000 deaths annually. Pharmacogenomic studies have shown that many ADRs are partially attributable to genetics. However, emerging data suggest that epigenetic mechanisms, such as DNA methylation (DNAm) also contribute to this variance.
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- Early worsening of plasma lipid levels (EWL), defined as a ≥5% change after one month, is linked to long-term lipid issues in patients treated with certain psychotropic medications.
- This study identified that low initial levels of total cholesterol, LDL-C, and triglycerides, along with high HDL-C levels, are significant risk factors for EWL, and integrating specific genetic variations (SNPs) can enhance prediction accuracy.
- Overall, clinical and genetic factors are important for predicting EWL and developing new-onset dyslipidaemia, suggesting the need for larger studies to improve these predictive models for clinical use.
Article Synopsis
- Genetic variants found in GWAS are mostly non-coding and have subtle effects on genes, while Mendelian disease variants are coding and directly influence diseases.
- The study connects common and rare genetic diseases by analyzing how common variants affect gene co-expression across various tissues, using a tool called Downstreamer on 88 GWAS traits.
- Key findings show that important downstream genes related to common traits, like height, are often linked to Mendelian disease genes, with many being located outside GWAS loci, indicating complex regulatory interactions.