Publications by authors named "M C SARRIS"
Cells need to migrate along gradients of chemicals (chemotaxis) in the course of development, wound healing, or immune responses. Neutrophils are prototypical migratory cells that are rapidly recruited to injured or infected tissues from the bloodstream. Their chemotaxis to these inflammatory sites involves changes in cytoskeletal dynamics in response to gradients of chemicals produced therein.
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- - The study aimed to determine if umbilical cord blood platelet lysate (UCB-PL) gel improves healing rates for diabetic foot ulcers (DFU) compared to normal saline dressing.
- - In this trial, 110 patients were divided into two groups; one received UCB-PL gel every three days while the other received saline, with ulcer sizes assessed over six months.
- - Results showed UCB-PL gel led to a significantly greater reduction in ulcer size, with 97.6% of patients in the UCB-PL group seeing improvement compared to 73% in the saline group.
Migrating cells must interpret chemical gradients to guide themselves within tissues. A long-held principle is that gradients guide cells via reorientation of leading-edge protrusions. However, recent evidence indicates that protrusions can be dispensable for locomotion in some contexts, raising questions about how cells interpret endogenous gradients in vivo and whether other mechanisms are involved.
View Article and Find Full Text PDFIntestinal mesenchymal cells encompass multiple subsets, whose origins, functions, and pathophysiological importance are still not clear. Here, we used the Col6a1 mouse, which targets distinct fibroblast subsets and perivascular cells that can be further distinguished by the combination of the CD201, PDGFRα and αSMA markers. Developmental studies revealed that the Col6a1 mouse also targets mesenchymal aggregates that are crucial for intestinal morphogenesis and patterning, suggesting an ontogenic relationship between them and homeostatic PDGFRα telocytes.
View Article and Find Full Text PDFBackground: COVID-19 caused by SARS-CoV-2 has been inducing an ongoing global health and economic emergency. Although viral pneumonia is the most striking presentation for COVID-19 patients, it has been noticed that some patients may also be accompanied with an abnormal liver function.
Methods: CT was performed in both lungs, and routine bloodwork and the blood metabolic panel were measured.