Direct Stereoselective Synthesis of 2-Deoxyglycosides via Visible-Light-Induced Photoacid-Catalyzed Activation of Glycosyl -[1-(-MeO-Phenyl)vinyl]benzoates (PMPVBs) as Donors.

The photoacid-catalyzed synthesis of 2-deoxy glycosides is presented using stable glycosyl -[1-(-MeO-Phenyl)vinyl]benzoate (PMPVB) donors and employing the eosin Y and diphenyl disulfide (PhSSPh) catalytic system in the presence of blue LED lights. The remote activation of the alkene functionality under the photoacid catalysis followed by a 5-- cyclization led to the generation of oxocarbenium ions that were trapped to provide the glycosylated products in excellent yields and decent selectivities under mild conditions. This method is also useful for the photoacid-catalyzed synthesis of -methoxybenzyl-alkyl ethers.

Strained Ion Pair Interactions-Driven Anion-Assisted Concerted Addition of Ketoximes/Aldoximes and Hydroxamic Acids to Glycals.

Oximes and hydroxylamides are notable for their role as coupling partners in organic synthesis. However, their direct application as acceptors in -glycosylation with glycal donors remains largely unexplored. Herein, we introduce a novel 2-deoxy glycosylation method for synthesizing N-O linked glycosides facilitated by sterically strained 2,4,6-tri--butylpyridinium salts.

Ibrutinib for therapy of steroid-refractory chronic graft vs. host disease: A multicenter real-world analysis.

To examine activity of ibrutinib in steroid-refractory chronic GVHD (SR-cGVHD) after FDA approval, we conducted a multicenter retrospective study. Data were standardly collected (N=270 from 19 centers). Involved organs included skin (75%), eye (61%), mouth (54%), joint/fascia (47%), GI (26%), lung (27%), liver (19%), genital (7%), other (4.

Determinants of Outcomes for Acute Myeloid Leukemia Patients Treated in a Community-Based Specialized Versus Non-Specialized Hospital Setting.

The treatment setting influences acute myeloid leukemia (AML) outcomes. Most cancer patients receive care in the community, yet few studies have evaluated the effectiveness of clinical programs outside of academic or National Cancer Institute (NCI)-designated cancer centers. This was a multi-level, case-controlled study of real-world outcomes for initial AML treatment in a community-based network for 1,391 patients with AML between 2011 and 2018.