Safety, tolerability and pharmacokinetics of subcutaneous cefazolin as an alternative to intravenous administration.

Background: Subcutaneous (SC) administration of antibiotics is a practical alternative to IV administration. Cefazolin is widely used for skin and soft tissue infections and other complex infections by IV administration.

Methods: In this prospective, cross-over self-controlled study, a single dose of SC cefazolin was administered to 15 stable inpatients established on IV cefazolin as part of their management plan.

Temperature Excursions in Cold Chain Management-Assessing the Accuracy of Refrigerator Temperature Probes.

Medications requiring refrigeration for stability are commonly used across hospitals. Temperature-sensitive medications may not have their temperature requirements maintained due to breaches in the cold chain, especially refrigerator failure. This is usually caused by malfunction of the refrigerator unit or by power outage.

Safety, tolerability and pharmacokinetics of subcutaneous meropenem as an alternative to intravenous administration.

Background: Subcutaneous delivery of antibiotics is a practical alternative to IV administration. Meropenem is commonly used to treat infections caused by resistant Gram-negative organisms.

Methods: This was a prospective, crossover self-controlled study in 11 stable inpatients established on meropenem.

Longer-term compliance benefits of oncology-specific smart pump drug error reduction systems.

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