MOMAST Downregulates AQP3 Expression and Function in Human Colon Cells.

The water channel AQP3 is an aquaglyceroporin expressed in villus epithelial cells, and it plays a role in water transport across human colonic surface cells. Beyond water, AQP3 can mediate glycerol and HO transport. Abnormal expression and function of AQP3 have been found in various diseases often characterized by altered cell growth and proliferation.

Targeted degradation of oncogenic KRASG12V triggers antitumor immunity in lung cancer models.

Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most frequently mutated oncogene in lung adenocarcinoma, with G12C and G12V being the most predominant forms. Recent breakthroughs in KRASG12C inhibitors have transformed the clinical management of patients with the G12C mutation and advanced our understanding of the function of this mutation. However, little is known about the targeted disruption of KRASG12V, partly due to a lack of specific inhibitors.

Mediating Role of Job Satisfaction in the Relationship Between Leisure-Time Physical Activity and Emotional State of Healthcare Workers: A Cross-Sectional Survey.

Background: Work-related stress among healthcare employees can lead to burnout, worsened mood, and job dissatisfaction. Although physical activity is known to enhance mood and mental health, its impact on job satisfaction and emotional well-being in healthcare workers is under-researched. This study aimed to explore the associations between leisure-time physical activity (LTPA), job satisfaction, and emotional state and to investigate the mediating role of job satisfaction in the effect of LTPA on the emotional state of healthcare workers.

Discovery of BBO-8520, a first-in-class direct and covalent dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C.

Approved inhibitors of KRASG12C prevent oncogenic activation by sequestering the inactive, GDP-bound (OFF) form rather than directly binding and inhibiting the active, GTP-bound (ON) form. This approach provides no direct target coverage of the active protein. Expectedly, adaptive resistance to KRASG12C (OFF)-only inhibitors is observed in association with increased expression and activity of KRASG12C(ON).