Application of a targeted amplicon sequencing panel to screen for insecticide resistance mutations in Anopheles darlingi populations from Brazil.

Large-scale surveillance and informed vector control approaches are urgently needed to ensure that national malaria programs remain effective in reducing transmission and, ultimately, achieving malaria elimination targets. In South America, Anopheles darlingi is the primary malaria vector and is responsible for the majority of Plasmodium species transmission. However, little is known about the molecular markers associated with insecticide resistance in this species.

Basic Science and Pathogenesis.

Background: The apolipoprotein ε4 (ApoE4) allele is a major risk factor for sporadic Alzheimer's disease (AD) and was shown to promote amyloid-β (Aβ) accumulation and mediate pathophysiological processes in AD. Although the molecular interaction between Aβ and ApoE is acknowledged, the precise nature of this interaction remains unclear. This study aims to explore the biophysical and biochemical nature of the interaction between Aβ and ApoE in the ε3 and ε4 isoforms.

High throughput phenotyping in soybean breeding using RGB image vegetation indices based on drone.

This study investigates the effectiveness of high-throughput phenotyping (HTP) using RGB images from unmanned aerial vehicles (UAVs) to assess vegetation indices (VIs) in different soybean pure lines. The VIs were accessed at various stages of crop development and correlated with agronomic performance traits. The field research was conducted in the experimental area of the Mato Grosso do Sul Foundation, Brazil, with 60 soybean pure lines.

XbaI polymorphism in the APOB gene and its association with increased cholesterol in children and adolescents: Ouro Preto study.

Atherosclerotic vascular changes can begin during childhood, providing risk for cardiovascular disease (CVD) in adulthood. Identifiable risk factors such as dyslipidemia accelerate this process for some children. The apolipoprotein B (APOB) gene could help explain the inter-individual variability in lipid levels among young individuals and identify groups that require greater attention to prevent CVD.