Publications by authors named "M C Press"
Peptidylglycine alpha-amidating monooxygenase (PAM) is the only enzyme known to catalyze C-terminal amidation, a final post-translational modification step essential for the biological activity of over 70 bioactive peptides, including adrenomedullin (ADM), calcitonin gene-related peptide (CGRP), amylin, neuropeptide Y (NPY), and others. Bioactive (amidated) peptide hormones play crucial roles in various physiological processes and have been extensively explored as therapeutic compounds in clinical and preclinical research. However, their therapeutic viability is limited due to their short half-life and, in most cases, the need for prolonged infusion to maintain effective concentrations.
View Article and Find Full Text PDFGenome-wide association studies have identified approximately 200 genetic risk loci for breast cancer, but the causal variants and target genes are mostly unknown. We sought to fine-map all known breast cancer risk loci using genome-wide association study data from 172,737 female breast cancer cases and 242,009 controls of African, Asian and European ancestry. We identified 332 independent association signals for breast cancer risk, including 131 signals not reported previously, and for 50 of them, we narrowed the credible causal variants down to a single variant.
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- The study investigates the role of CCND1 gene amplification in the prognosis of hormone receptor-positive breast cancer patients, particularly in the context of resistance to endocrine therapy.
- A cohort of 894 breast cancer patients was analyzed, revealing that 12.9% had CCND1 amplification, predominantly in luminal B-like and HER2-positive tumor types.
- The findings indicate that while CCND1 amplification is common in certain breast cancer subtypes, it does not show significant differences in disease-free survival or overall survival among HR-positive, HER2-negative patients.
Adrenomedullin (ADM) is a multifaceted peptide hormone involved in numerous physiological processes, including vascular stability, vasodilation, angiogenesis, and anti-inflammatory responses. The processing of ADM results in several fragments, including midregional proadrenomedullin (MR-proADM), and glycine-extended ADM (ADM-Gly) and bioactive ADM (bio-ADM). MR-proADM, the stable ADM fragment, and bio-ADM, the active form of ADM with a short half-life, have been shown to be potent biomarkers in a variety of pathologies.
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- - Cardiovascular disease (CVD) remains a top cause of death globally, despite advancements in treatment and diagnosis.
- - Older women generally develop CVD later than men, often linked to higher rates of obesity and diabetes.
- - Understanding sex differences in acute coronary syndrome (ACS) is crucial for improving management and outcomes for women affected by the condition.