[Relative bioavailability in man of 2 pharmaceutical forms of canrenone].

The relative bioavailability of 100 mg canrenone capsules and the commercial 50 mg capsules has been determined in 12 healthy male subjects. The study was conducted in a cross over design. After the absorption phase canrenone plasma concentrations followed a biexponential decay.

Quantitative thin-layer and high-performance liquid chromatographic determination of lorapride in biological fluids and a pharmacokinetic study in humans.

Lorapride has been determined in plasma, red blood cells, and urine by HPLC. The detection was performed at a short wavelength (226 nm), resulting in a detection limit of 10 ng/mL (amount injected was 3.5 ng).

[Metabolism of beta-adrenergic substances. Therapeutic implications].

The metabolism of the main beta-adrenoceptor stimulants which are not catechol derivatives involves conjugation with glucuronic or sulphuric acids in several animal species and conjugation with sulphuric acid in man. These drugs are not metabolized by MAO like isoproterenol or by COMT like the catechol derivatives: isoproterenol, trimetoquinol, hexoprenaline and rimiterol. Sulphate conjugation, in man, increases with the number of hydroxy groups.